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84485-00-7 Natural Health Weight Loss Powder Sibutramine Steroids For Pharmaceutical
Weight Loss Powder 99% 84485-00-7 Natural Health Fat Loss Powder Sibutramine Steroids For Pharmaceutical
1. Quick Detail: Sibutramine Hydrochloride
CAS No: 84485-00-7
Appearance: White powder, soluble in methanol.
Sibutramine Hcl; Sibutramine・HCL; MERIDIA
CAS Registry Number
348.119°C at 760 mmHg
0mmHg at 25°C
Sibutramine (usually in the form of the hydrochloride monohydrate salt) is an oral anorexiant. Until 2010 it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise. 2. Applications: Medicine reducing weight and antidepressants.
Sibutramine is well absorbed from the GI tract (77%), but undergoes considerable first-pass metabolism, reducing its bioavailability. The drug itself reaches its peak plasma level after 1 hour and has also a half-life of 1 hour. Sibutramine is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically-active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively. Peak plasma concentrations of active metabolites 1 and 2 are reached after three to four hours. The following metabolic pathway mainly results in two inactive conjugated and hydroxylated metabolites (called metabolites 5 and 6). Metabolites 5 and 6 are mainly excreted in the urine. 3. Specifications: