Product name: Exemestan,Aromasin
Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione
Molecular Formula: C20H24O2
Molecular Weight: 296.40
Grade: Medicine grade
Appearance: White to almost white powder
Assay: 99.5% min
Exemestane is known as a hormonal breast cancer treatment.
Some breast cancers need the hormone oestrogen to grow. In women who have been through the menopause, the main source of oestrogen is through the change of sex hormones called androgens into oestrogen. An enzyme called 'aromatase' is needed for this change to occur. Exemestane works by inhibiting (or blocking) this enzyme. This reduces the amount of oestrogen in your body, which slows the growth of the cancer cells.
Fuction of Exemestane
1) Exemestane for breast cancer prevention:
Chemoprevention of breast cancer is an effective strategy to reduce the incidence of this disease in women at risk. The first agents to show a significant chemopreventive effect were the SERMs tamoxifen and raloxifen. An updated comprehensive analysis of all SERM prevention trials showed that they are able to reduce the incidence of breast cancer in high- and average-risk women, an effect that is sustained by a reduction in ER-positive invasive breast cancer
2) Exemestane is a third-generation irreversible steroidal inactivator of the aromatase enzyme and is effective in all the treatment settings for breast cancer, including chemoprevention.
In the metastatic setting, exemestane has been extensively investigated as the first-line, second-line, and further-line treatment and is now registered for the treatment of postmenopausal women with advanced hormone-receptor-positive breast cancer whose disease has progressed following antiestrogen therapy. Of note, the potential lack of cross-resistance with NSAIs yields additional opportunities in the treatment sequence of endocrine agents. Furthermore, based on clinically meaningful results, exemestane with everolimus represents an effective therapeutic option for a disease that has progressed after exposure to NSAIs.
Exemestane is generally well tolerated, with a side effect profile similar to that of other AIs and including menopausal symptoms, arthralgia, bone loss, and altered lipid metabolism.
|Description||White Crystalline Powder||White Powder|
|Loss On Drying||0.5%max||0.19%|
|Specific Rotation||+288°~ +298°||+290.2°|
|Residue On Ignition||0.1%max||0.03%|
|Heavy Metals||20PPm max||<10PPm|
|Conclusion||The specification conform with USP35|
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|Contact Person :||Anne|