|Letrozole Basic information,important|
[Use 1] Pyrrole-type aromatase inhibitor. For the treatment of breast cancer
Letrozole is a new generation of highly selective aromatase inhibitors, which are synthetic benzyltriazole derivatives. By inhibiting aromatase, estrogen levels are reduced, thereby eliminating the stimulating effect of estrogen on tumor growth. The in vivo activity is 150-250 times stronger than the first-generation aromatase inhibitor, aminoglutethimide. Because of its high selectivity, it does not affect glucocorticoids, mineralocorticoids and thyroid function. High doses have no inhibitory effect on the secretion of adrenocortical steroids and therefore have a higher therapeutic index. Various preclinical studies have shown that letrozole is not potentially toxic to systemic and target organs, has no mutagenicity and carcinogenic effects, and has less side effects and good tolerance, with other aromatase inhibitors and antibiotics. Compared with estrogen drugs, the anti-tumor effect is stronger. It is suitable for the treatment of postmenopausal patients with advanced breast cancer who are not effective in anti-estrogen therapy and early treatment of breast cancer.
In December 2005, the UK Drug and Health Products Regulatory Authority approved the use of letrozole (Fron) produced by Novartis AG in Switzerland for the treatment of breast cancer patients, allowing them to be used in surgically treated, postmenopausal hormone-positive early invasive breasts. Cancer patients. This is the second aromatase inhibitor approved after the approval of AstraZeneca's Ruining in June 2005. Both drugs in clinical trials have shown a better risk of breast cancer recurrence compared to current standard tamoxifen treatment.
The difference between letrozole and anastrozole. Letrozole: suitable for postmenopausal advanced breast cancer, mostly used for the treatment of second-line treatment after anti-estrogen treatment failure.
Anastrozole: a potent and selective triazole aromatase inhibitor that inhibits the aromatase of cytochrome P-450 and blocks estrogen biosynthesis, while estrogen stimulates breast cancer cells The main factor of growth. The 50% inhibitory concentration (IC50) of this product on human placental aromatase is 15nmol/L .
1. Treatment of postmenopausal advanced breast cancer (estrogen receptor, progesterone receptor positive or receptor status unknown), mostly used for second-line treatment after anti-estrogen treatment failure;
2. First-line treatment for postmenopausal breast cancer with locally advanced or diffuse (foreign data);
3. Extended adjuvant therapy for postmenopausal breast cancer patients who have received tamoxifen standard adjuvant therapy for 5 years (foreign data);
4. Postoperative adjuvant therapy for early hormone-positive breast cancer patients 
2.5 mg each time, orally, once a day. There is no clinical correlation between gender, age, and liver and kidney function and letrozole, so elderly patients and patients with impaired liver and kidney function do not have to adjust the dose. According to years of clinical experience, it also has the effect of promoting ovulation .
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Femara (letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer.
In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more (1). However, it’s use and benefits are not limited to eliminating estrogen in women.
For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.
Parallel Bars Leg Raise can help you increase the strength of your abdomen while deepening the separation of abdominal muscle lines, so that the abdominal muscles achieve the best results. The premise must be that you have confidence in your abdominal muscles, because this action requires higher, of course, the stimulation is deeper.
Target exercise muscle: lower rectus abdominis (lower abdomen)
1. Hold the parallel bars with both hands to support the body, the toes are straight and the legs are close together, so that the body is in a straight vertical ground, the eyes are flat, the shoulders are relaxed, the trapezius muscles are not allowed to participate in the exercise, and then the inhalation is deep, and the abdomen is exhaled. Tightening, legs raised to the front of the body, knees and ankles do not bend, always keep straight, pay attention to the legs themselves, do not force, keep the muscles tightened.
2. When the legs are lifted parallel to the ground, stop for 1-2 seconds, fully feel the feeling of tightening the abdominal muscles, then slowly reduce the legs, the legs are always close together, do not separate, then the abdomen The muscles are again exerted, and it is enough to practice repeatedly.
1. The action is more difficult and the overall quality is high. So you should put the parallel bars and legs on the abdomen to practice the first action.
2. The action requires a strong arm to support the parallel bars, otherwise there is no chance to get exercise without supporting the abdomen. Therefore, you should first raise the arm strength to a certain level, otherwise you will not be able to practice.
3. The body should not swing back and forth during the movement, which will affect the abdominal muscles. Therefore, the coordination of the body and the guarantee of the ability of the muscles of the body to work together are prerequisites.
4. When lifting the legs, do not separate the legs, straighten, otherwise it will be very labor-saving, which will affect the exercise effect.
5. The requirements for breathing are equally high for all difficult exercises. The rhythm of inhalation when your legs are raised and your legs fall will be maintained. In this way, the practice of breathing with reasonable breathing is extended many times than the number of practicing exercises that do not pay attention to breathing. The exercise effect is more obvious.
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