Basic Information
Type of medicine Basic medicine
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Drug Name Chorionic
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English name |
Chorionic Gonadotrophin
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Chinese name |
chorionic gonadotropin; pituitary gonadotropin
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English alias |
Antuitrin S; Gonatrophin
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Quick Details:
Ingredients
The main ingredient of this product is chorionic gonadotropin, plus suitable excipients, freeze-dried sterile products. Chorionic gonadotropin is a chorionic gonadotropin extracted from the urine of pregnant women.
Excipient name: dextran, mannitol, water for injection.
Source (name), content (potency)
This product is a chorionic gonadotropin extracted from the urine of pregnant women. The potency per 1 mg should not be less than 4,500 units.
Legal requirements
This product should be extracted from the urine of healthy people, and the production process should comply with the current version of the "Good Manufacturing Practices". This product needs to be treated by a suitable process in the production process to remove or inactivate any viruses such as hepatitis virus, human immunodeficiency virus and prion.
Traits
This product is a white or off-white powder.
This product is soluble in water and insoluble in ethanol, acetone or ether.
Identification
According to the method under the measurement of the potency, the results should be such that the uterus of the female mice can gain weight.
an examination
Estrogen
Three female mice weighing 18-20 g were taken and the ovaries were removed. 2 to 3 weeks later, subcutaneous injection of 1250 units of sodium chloride injection per 1ml, 0.2ml each time, the first day of the afternoon, the second day of the afternoon, the afternoon, the third day of the morning; On the fourth, fifth, and sixth mornings, the mice were washed with a small amount of sodium chloride injection to make a vaginal smear, which was observed under a low power microscope and should not be positive (positive reaction means Most of the tablets are keratinocytes or epithelial cells).
remaining solvent
Ethanol
Take 0.1g of this product, accurately weigh it, place it in the empty bottle, add 2ml of water to dissolve, seal, and use it as a sample solution; take another amount of absolute ethanol, accurately weigh it, and dilute with water to make 0.25mg per 1ml. The solution was accurately weighed in 2 ml, placed in an empty bottle, sealed, and used as a reference solution. According to the residual solvent determination method (2010 edition of the second edition of Appendix VIIIP of the Pharmacopoeia), using polyethylene glycol as the fixing solution; the initial temperature is 60 ° C, maintained for 5 minutes, and the temperature is raised to 200 ° C at a rate of 50 ° C per minute. , maintain for 15 minutes; the injector temperature is 200 ° C; the detector temperature is 250 ° C; the headspace bottle equilibrium temperature is 90 ° C, the equilibration time is 20 minutes, the reference solution and the test solution are separately injected into the headspace, recording Chromatogram. Calculated by peak area according to the external standard method, it should meet the requirements.
Moisture
Take this product, according to the moisture determination method (2010 edition of the second edition of the Pharmacopoeia Appendix VIII M first method A), the water content should not exceed 5.0%.
Hepatitis B surface antigen
Take this product, add 0.9% sodium chloride solution to make 10mg solution per 1ml, measured according to the kit instructions, should be negative.
Abnormal toxicity
Take this product, add sodium chloride injection to dissolve and make a solution containing 2000 units per 1ml, check according to law (2010 edition of the second edition of the Pharmacopoeia Appendix XIC), according to intravenous injection, should meet the requirements.
Bacterial endotoxin
Take this product and check it according to law (Appendix XI E of the Pharmacopoeia, 2010). The amount of endotoxin per unit of gonadotropin should be less than 0.010 EU.
Potency determination
Accurately weigh the appropriate amount of this product and the velvet stimulating standard. According to the indicated potency, add 0.9% sodium borate solution containing 0.1% bovine serum albumin to dissolve and quantitatively dilute to make a solution containing 10 units per 1ml. , with a new match. According to the velvet gonadotropin bioassay (2010 edition of the Pharmacopoeia Part II Appendix XIIE), it should meet the requirements, and the measured result should be 80% to 125% of the labeled amount.
Fitness Tips~~
The Reverse Curl is generally a barbell. The main exercise targets are the forearm extension muscles, that is, the outside of the forearm, and the diaphragm of the upper arm.
Target muscle group: forearm muscle group
This exercise is mainly to exercise the wrist muscles, the extension of the finger muscles, exercise the diaphragm and diaphragm, and also have a slight exercise effect on the biceps.
Action essentials:
1. Preparation: The feet are separated, shoulder width, hands are holding the barbell, the middle distance grip; arms folded, holding the barbell in front of the thigh; the arms are close to the sides of the body, the knees are slightly flexed.
2. Training action: slowly raise your elbow and lift the barbell. You can lift as much as you can, but do not participate in the movement of the upper arm; pause briefly, then slowly lower the barbell and return to the starting position; repeat the above actions until the group is completed. Exercise.
Precautions:
1. During the whole movement, the arm should always be close to the sides of the body. As you slowly do this exercise, you will feel the arm is extremely hard. Try not to move back and forth between the elbows. When the barbell is bent to the apex of the action, the forearm's extensor muscles must still be under gravity. Lift the barbell elbow, the body should not swing and assist. The weight load used in the forearm exercises should not be too large.
2. This movement will also train the other arms of the lower arm and the big arm, which is very useful for increasing the arm circumference.
3. Pay attention to the difference between the barbell curling and gripping method of exercising the biceps. The different effects of the gripping method are completely different.