Genotropin Pen 12mg Goquick Pfizer Medical For Building Muscle Gear

What GENOTROPIN is used for

GENOTROPIN is a growth hormone.

GENOTROPIN is used to treat:

Short stature caused by the lack of growth hormone.

GENOTROPIN promotes the growth of the long bones (for example, upper legs) in children with reduced height due to lower than normal levels of growth hormone.

Reduced growth in girls with Turner syndrome.

Turner syndrome is a genetic disorder found in females. The condition may cause short stature and ovaries to not fully develop.

Children with Prader-Willi syndrome.

Prader-Willi syndrome is a genetic disorder that may cause short stature, low muscle tone and a constant feeling of hunger.

GENOTROPIN helps to improve growth and body composition. It also helps to reduce excessive fat and improve muscle mass.

Diet restrictions may still be necessary during treatment with GENOTROPIN.

Children with kidney disease, to help them grow at a normal rate.

Adults who do not produce enough natural growth hormone.

However, your doctor may prescribe GENOTROPIN for another purpose. Ask your doctor if you have any questions about why GENOTROPIN has been prescribed for you.

GENOTROPIN 12 mg powder for injection with solvent.

Two chamber cartridge, for use in a Pfizer injection device (GENOTROPIN Pen) or sealed in a disposable pre-filled Genotropin pen Pfizer 12mg GoQuick. The cartridge contains 5 mg somatropin, glycine, sodium dihydrogen phosphate anhydrous, disodium phosphate anhydrous, water for injection, m-cresol, mannitol.

GENOTROPIN 5.3 mg powder for injection with solvent.

Two-chamber cartridge, for use in a Pfizer injection device (GENOTROPIN Pen) or sealed in a disposable pre-filled Genotropin pen Pfizer 12mg GoQuick. The cartridge contains 5.3 mg somatropin glycine, sodium dihydrogen phosphate anhydrous, disodium phosphate anhydrous, water for injection, m-cresol, mannitol. GENOTROPIN 12 mg powder for injection with solvent.

Two-chamber cartridge, for use in a Pfizer injection device (GENOTROPIN Pen) or sealed in a disposable pre-filled Genotropin pen Pfizer 12mg GoQuick. The cartridge contains 12 mg somatropin, glycine, sodium dihydrogen phosphate anhydrous, disodium phosphate anhydrous, water for injection, m-cresol, mannitol.

USES

Actions

Genotropin pen Pfizer 12mg (36iu) – Somatropin is a potent metabolic hormone of importance for the metabolism of lipids, carbohydrates and proteins. In children with inadequate endogenous growth hormone and in

children with Prader-Willi syndrome, somatropin stimulates linear growth and increases growth rate. In adults, as well as in children, somatropin maintains a normal body composition by increasing nitrogen retention and stimulation of skeletal muscle growth, and by mobilisation of body fat. Visceral adipose tissue is particularly responsive to somatropin. In addition to enhanced lipolysis, somatropin decreases the uptake of triglycerides into body fat stores. Serum concentrations of IGF-I (Insulin-like Growth Factor-I), and IGFBP3 (Insulin-like Growth Factor Binding Protein 3) are increased by somatropin. In addition, the following actions have been demonstrated:

– Lipid metabolism: Somatropin induces hepatic LDL cholesterol receptors, and affects the profile of serum lipids and lipoproteins. In general, administration of somatropin to growth hormone deficient patients results in reductions in serum LDL and apolipoprotein B. A reduction in serum total cholesterol may also be observed.

– Carbohydrate metabolism: Somatropin increases insulin but fasting blood glucose is commonly unchanged. Children with hypopituitarism may experience fasting hypoglycaemia. This condition is reversed by somatropin.

– Water and mineral metabolism: Growth hormone deficiency is associated with decreased plasma and extracellular volumes. Both are rapidly increased after treatment with somatropin. Somatropin induces the retention of sodium, potassium and phosphorus.

– Bone metabolism: Somatropin stimulates the turnover of skeletal bone. Long-term administration of somatropin to growth hormone deficient patients with osteopenia results in an increase in bone mineral content and density at weight-bearing sites.

– Physical capacity: Muscle strength and physical exercise capacity are improved after longterm treatment with somatropin. Somatropin also increases cardiac output, but the mechanism has yet to be clarified. A decrease in peripheral vascular resistance may contribute to this effect.

GENOTROPIN improves energy, vitality, memory functions and subjective well-being.

Pharmacokinetics

Absorption

The bioavailability of subcutaneously administered GENOTROPIN is approximately 80% in both healthy subjects and growth hormone deficient patients. A subcutaneous dose of 0.035 mg/kg of GENOTROPIN results in plasma Cmax and tmax values in the range of 13-35 ng/ml and 3-6 hours respectively.

Elimination

The mean terminal half-life of GENOTROPIN after intravenous administration in growth hormone deficient adults is about 0.4 hours. However, after subcutaneous administration, half-lives of 2-3 hours are achieved. The observed difference is likely due to slow absorption from the injection site following subcutaneous administration.

Sub-populations

The absolute bioavailability of GENOTROPIN seems to be similar in males and females following s.c. administration. Information about the pharmacokinetics of GENOTROPIN in geriatric and paediatric populations, in different races and in patients with renal, hepatic or cardiac insufficiency is

either lacking or incomplete.

Before you use GENOTROPIN

When you must not use GENOTROPIN (discuss with your doctor)

Your doctor will not prescribe GENOTROPIN if you:

are a child and have closed epiphyses (this means that your bones have finished growing).

have an active tumour or evidence of cancer growth.

are currently being treated for cancer.

have a serious injury or illness, or surgical procedures, requiring intensive care.

have Prader-Willi syndrome and are severely overweight or have marked difficulty breathing.