Growth Hormone Peptides Bodybuilding Myostain GDF-8 Muscle Mass

GDF-8 Description:

GDF-8 (propeptide-Fc) is a myostatin inhibitor of muscle growth and development process. Myostatin is present in the healing process of muscles and its nature is to inhibit myogenesis (the process of formation of muscular tissue). Scientists have been studying a new method to enhance the repair and regeneration of both muscle and bone in certain injuries through a new recombinant myostatin propeptide.

GDF-8 Structure and mechanism of action:

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

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