CAS 62568-57-4 DSIP Raw Powder Delta Sleep - Inducing Peptide Growth Hormone
1 kit
CAS 62568-57-4 DSIP Raw Powder Delta Sleep - Inducing Peptide Growth Hormone
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Basic Infomation
Place of Origin: China
Brand Name: DSIP
Certification: COA
Model Number: DSIP 5mg*10vials
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62568-57-4 DSIP Raw Powder


Peptide Growth DSIP Raw Powder

Payment & Shipping Terms
Packaging Details: standard package
Delivery Time: 3days
Payment Terms: Bank transfer and Bitcoin.
Supply Ability: 10000kit/month
Name: DSIP
Appearance: White Powder
Grade: Pharmaceutical
MOQ: 1 Kit
Product Description

DSIP Raw Powder CAS 62568-57-4 Delta Sleep-Inducing Peptide Growth Hormone


Product name Delta sleep-inducing peptide
Other name DSIP
CAS No 62568-57-4
Molecular formula C35H48N10O15
Molecular Weight 848.81




Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

A modulation or 'programming' interaction of delta sleep-inducing peptide (DSIP) with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine. The induction of cerebral MAO-A activity, a pronounced influence on the circadian rhythms of locomotion and intracerebral neurotransmitter as well as plasma protein and cortisol concentrations has been reported. DSIP was also shown to counteract experimentally induced stress situations in animals.

An improvement of the psychomotor performance and the concentration capacity in humans beside sleep normalization and pronounced effects on withdrawal symptoms including pain states in alcoholics and opiate addicts was discovered. This encouraged a pilot study for a possible action of the peptide in humans suffering from chronic pronounced pain episodes. DSIP has stress-protective, antiseizure, and immunomodulating effects.


DSIP Function:


Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting


DSIP antiserum and antibodies.

Roles In Endocrine Regulation

Decreases basal corticotropin level and blocks its release.

Stimulates release of luteinizing hormone (LH).

Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.


Structure And Interactions:


DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.


CAS 62568-57-4 DSIP Raw Powder Delta Sleep - Inducing Peptide Growth Hormone 0


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