Follistatin 344/ FST 344
Standard: USP Grade, GMP
Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Follistatin is part of the inhibin-activin-follistatin axis.
Currently there are three reported isoforms, FS-288, FS-300, and FS-315. Two, FS-288 and FS-315, are known to be created by alternative splicing of the primary mRNA transcript. FS-300 (porcine follistatin) is thought to be the product of posttranslational modification via truncation of the C-terminal domain from the primary amino-acid chain.
Although FS is ubiquitous its highest concentration has been found to be in the female ovary, followed by the skin.
The activin-binding protein follistatin is produced by folliculostellate (FS) cells of the anterior pituitary. FS cells make numerous contacts with the classical endocrine cells of the anterior pituitary including gonadotrophs.
In the tissues activin has a strong role in cellular proliferation, thereby making follistatin the safeguard against uncontrolled cellular proliferation and also allowing it to function as an instrument of cellular differentiation. Both of these roles are vital in tissue rebuilding and repair, and may account for follistatin's high presence in the skin.
In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion. The source of follistatin in circulating blood plasma has yet to be determined, but due to its autocrine nature speculation suggests the endothelial cells lining all blood vessels, or the macrophages and monocytes also circulating within the whole blood, may be sources.
Follistatin is involved in the development of the embryo. It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition of BMPs allows neuroectoderm to arise from ectoderm, a process which eventually forms the neural plate. Other inhibitors involved in this process are noggin and chordin.
Follistatin and BMPs are also known to play a role in folliculogenesis within the ovary. The main role of follistatin in the oestrus/menstrus ovary, so far, appears to be progression of the follicle from early antral to antral/dominant, and importantly the promotion of cellular differentiation of the estrogen producing granulosa cells (GC) of the dominant follicle into the progesterone producing large lutein cells (LLC) of the corpus luteum.
Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass. In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength.
Follistatin (FST) is a secreted glycoprotein that was first identified as a folliclestimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin 315 is a 34.7 kDa protein containing amino acids 30-344 of the FST-344 protein.
Follistatin 344 Application:
Follistatin-344 is also the perfect choice for athletes who are no longer able to exercise regularly, or those who have stopped playing sports, but want to stay though, in the form of massive muscle mass. It has been shown that the smaller the load on muscles and less physical activity, the higher the concentration of the subsequent Myostatin.
Peptide Follistatin-344 also has important implications for tissue rejuvenation. His pronounced anti-aging effect is comparable to that of Melatonin and other peptides, positive counteracting aging.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
|Testosterone Acetate||Trenbolone Acetate||MGF 2mg|
|Testosterone Cypionate||Trenbolone Enanthate||PEG MGF 2mg|
|Testosterone Decanoate||Boldenone Acetate||CJC-1295 with DAC 2mg|
|Testosterone Enanthate||Boldenone undecylenate||CJC-1295withoutDAC 2mg|
|Testosterone Isocaproate||Boldenone Cypionate||PT-141 10mg|
|Testosterone Phenylpropionate||Boldenone Propionate||MT-1 10mg|
|Testosterone Propionate||Nandrolone Decanoate||MT-2 10mg|
|Testosterone Undecanoate||Nandrolone phenylpropionate||GHRP-2 5mg|
|Mesterone||Nandrolone undecylate||GHRP-6 5mg|
|Testosterone Sustanon 250||Nandrolone cypionate||GHRP-6 10mg|
|Clostebol Acetate||Nandrolone propionate||Ipamorelin 2mg|
|Methenolone Enanthate||Drostanolone Propionate||Sermorelin 2mg|
|Methenolone Acetate||Drostanolone Enanthate||Oxytocin 2mg|
|Anavar||Tadalafil||pentadecapeptide BPC 157 2mg|
|Winstrol||Vardenafil||GH 176-191 2mg|
|Clomifene citrate||Dianabol||Triptorelin 2mg|
|Toremifene citrate||Tamoxifen Citrate||Tesamorelin 2mg|
|Selank 5mg||DSIP 2mg||Gonadorelin 10mg|
|Contact Person :||Anne|